Alzheimer's (AD) disease is foremost of the neurodegenerative diseases affecting cognition. Though memory, out of all cognitive functions of the brain, received much attention, the nonmemory cognitive functions including the higher brain functions, are equally important. In fact...
Open access
Research Article10.9734/ijbcrr/2020/v29i330177
Alzheimer’s disease (AD) is a neuro-degenerative disease, causing gradual decline in memory function in the affected patients. The loss of memory makes their existence miserable. It is first noticed and reported by the patient’s care takers. The clinicians objectively assess the...
Open access
Research Article10.9734/ijbcrr/2020/v29i230168
Amyloid plaques and Tau tangles, constitute the pathological hallmarks of the brains of the patients suffering from Alzheimer’s disease. They are identified as far back as 1996 by Alois Alzheimer, a German psychiatrist and neuropathologist, but till this date, how they produce ne...
Open access
Research Article10.9734/ijbcrr/2020/v29i130163
Metformin is the widely prescribed first line oral antidiabetic drug used in diabetes mellatus, type 2 . The global sales turnover of metformin runs into millions of dollars. The Increased risk of metformin (Met) users for developing Alzheimer disease (AD)is reported first in a...
Open access
Research Article10.9734/ijbcrr/2019/v26i330101
The presence of fat, beyond physiological limits, in organs, other than the adipose tissue, like the liver, the skeletal muscle, the heart and the pancreas etc is called ectopic fat. It causes specific organ dysfunction in the tissues concerned. The importance of the ectopic fat...
Open access
Research Article10.9734/ijbcrr/2019/v25i430083
Decreased insulin secretion due to beta cell dysfunction of the pancreas and defective utilization of insulin due to insulin resistance / Hyperinsulinemia are two important issues in the pathogenesis of DM2. There are many explanations in the literature to account for these two o...
Open access
Research Article10.9734/IJBCRR/2018/40500
Metformin, the antihyperglycaemic drug, though in use since 1957 eluded as to its mechanism of action till date. There is some truth but not the whole truth, in even the much-favoured mechanisms of AMP-stimulated protein kinase (AMPK) stimulation and inhibition of complex 1 of E...
Open access
Research Article10.9734/IJBCRR/2017/39028
Hyperglycaemia in patients admitted in intensive care units (ICU) with acute myocardial infarction is a common phenomena observed. This unique situation of cardiogenic insulin resistance does not spare diabetics or non -diabetics. It is in addition to the inherent insulin resista...
Open access
Research Article10.9734/IJBCRR/2017/37576
Randle cycle (1963) is about substrate competition between products of glycolysis and β–oxidation to capture the citric acid cycle for further oxidation. Acetyl –CoA, the end product of both the energy metabolisms, when accumulates in mitochondrial matrix beyond the oxidative ca...
Open access
Research Article10.9734/IJBCRR/2017/35088
Many theories have been put forward to explain insulin resistance in DM2. The cause of insulin resistance still remained an enigma till date. Defect in insulin signaling pathway is one such possibility considered for insulin resistance in DM2. For insulin signal transduction to o...
Open access
Research Article10.9734/IJBCRR/2016/24489