Mechanisms of Phorbol Ester Toxicity, Determined by Molecular Modelling
A. Wakandigara, L. R. M. Nhamo, J. Kugara & P. Mushonga · International Research Journal of Pure and Applied Chemistry · 2020
Phorbol esters are toxic phytochemicals, whose main biological target is protein kinase C. They bind irreversibly to the protein, causing cell damage. Using computer modelling, we have determined, for the first time, features and mechanisms that lead to the toxicity of phorbol es...
Open access
Research Article
10.9734/irjpac/2020/v21i1830267