Regioselectivity in the Multicomponent Reaction of 5-aminopyrazoles, Meldrum’s Acid and Triethyl Orthoformate
Afaf M. Abdel Hameed, Ahmed Moukhtar Nour-Eldin, Michael Magdy Ibrahim & Kamal Usef Sadek · Chemical Science International Journal · 2015
A regioselective multicomponent synthesis of pyrazolo[1,5-a]pyrimdines-7(4H)-ones 5 is reported. The reaction proceeded regioselectively via initial Michael addition of exocyclic amino function to the intermediately formed 5-ethoxymethylene Meldrum’s acid followed by a ring o...
Open access
Research Article
10.9734/ACSJ/2015/18903