In this study, high fat diet was fed to rats and the amount of vemurafenib in rat plasma was determined by the developed liquid chromatography with tandem mass spectrometry. The calibration curve was linear between 0.01 and 0.8 µg mL−1 vemurafenib with 0.999 regression coefficien...
Open access
Research Article10.9734/jpri/2021/v33i40B32285
In this study, the pKa value of vemurafenib was determined by the dependence of the retention factor on the pH of the mobile phase. The change of pKa in the different acetonitrile fraction ranging between 57.5 and 62.5% (v/v) was studied by using an LC-UV method. Additionally, a...
Open access
Research Article10.9734/jpri/2020/v32i3630986
Vitamin D deficiency is now recognized as a pandemic with implications for multi-organ systems including bone health and immunological processes. Low levels have been associated with several chronic and infectious diseases. The aim of the study was to evaluate the prevalence of v...
Open access
Research Article10.9734/jpri/2020/v32i2230781