Investigation of Low Bioavailability Using Physiologically Based Pharmacokinetic Modeling: A Case Example (Lassbio-596)
Manuela de Lima Toccafondo Vieira, Lídia Moreira Lima, Eliezer J. Barreiro & Carlos Alberto Tagliati · Current Journal of Applied Science and Technology · 2014
Aim: Investigate the possible mechanism (s) of the poor bioavailability of a lipophilic compound in rats using the physiologically based pharmacokinetic (PBPK) modeling approach. Methodology: A rat PBPK model was constructed using data from intravenous administration, and verifie...
Open access
Research Article
10.9734/BJAST/2015/13527