Erens Spiff Ekprikpo

Translating Vascular Biology into Clinical Benefit: A Critical Narrative Review of Sickle Cell Thromboinflammation in West Africa

Erens Spiff Ekprikpo, Stella Urekweru Ken-Ezihuo, Beauty Eruchi Echonwere-uwikor & Zaccheaus Awortu Jeremiah · International Blood Research & Reviews · 2026

Sickle cell disease is a systemic vasculopathy in which intravascular haemolysis, endothelial activation, leukocyte and platelet recruitment, and coagulation activation operate as a single self-reinforcing process now commonly described as thromboinflammation. Most of the mechani...