Mamadou Guy-Richard Koné, Georges Stephane Dembele, Bafétigué Ouattara, Adama Niaré, N’nan Akau Amandine Kouamé, Panaghiotis Karamanis & Nahossé Ziao·Chemical Science International Journal·2023
Cancer is any disease characterised by the rapid proliferation of abnormal cells in normal body tissue. Recent years have been marked by an increase in the number of cases of cancer, particularly that of the prostate. Cancer can affect any part of the body. Despite the efforts ma...
Open access
Research Article10.9734/CSJI/2023/v32i4852
This reactivity study was performed on seven molecules of a 2,3-dihydro-1H-perimidine series using density functional theory at the B3LYP / 6-311 G (d, p) level. Calculation of the dipole moment showed that compound 4 is more soluble in aqueous medium. The study of frontier molec...
Open access
Research Article10.9734/irjpac/2022/v23i130451
Siriki DOUMBIA, Niameke Jea Baptiste KANGAH, Georges Stephane Dembele, Nanou Tieba Tuo & Charles Guillaume Kodjo·Chemical Science International Journal·2025
The objective of this work is to design in silico new thiourea derivatives with improved potential anticancer activities of the breast of the MCF-7 strain. Fifty (50) new molecules were generated. All the generated compounds belong to the applicability domain of the model. Only t...
Open access
Research Article10.9734/CSJI/2025/v34i5998
Fandia Konate, Fatogoma Diarrrassouba, Georges Stephane Dembele, Mamadou Guy-Richard Koné, Bibata Konate & Nahossé Ziao·Chemical Science International Journal·2021
The purpose of this study is to develop a QSAR model predictive of the antimalarial activity of a series of Dihydrothiophenone molecules using quantum chemical methods. The molecules were optimized from the B3LYP/6-31G (d, p) level of theory. The extracted descriptors are the vib...
Open access
Research Article10.9734/CSJI/2021/v30i830244
Adama Niaré, Abadê Ange-Boris N’guessan, Akassa Marius Bernard Djako, Georges Stephane Dembele, Mamadou Guy-Richard Koné & Yaya Yéo·Chemical Science International Journal·2024
Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis. It remains a significant public health challenge worldwide. In 2022, approximately 10.6 million people were diagnosed with tuberculosis, and 1.3 million individuals lost their lives to the d...
Open access
Research Article10.9734/CSJI/2024/v33i6939
Mamadou Guy-Richard Koné, Lamoussa Ouattara, Kouakou Nobel N’Guessan, Georges Stephane Dembele, Panaghiotis Karamanis & Nahossé Ziao·Chemical Science International Journal·2024
In recent years, the number of cancer cases are increasing particularly that of prostate. In this work, we were interested in anticipating dihydropyrazole-cancer cell interactions and their anti-prostatic activity by studying the chemical reactivity and stability of a series of s...
Open access
Research Article10.9734/CSJI/2024/v33i6929
Breast cancer is a major public health issue and justifies the ongoing search for new active and selective molecules. In this study, a QSAR (Quantitative Structure-Activity Relationship) model was developed to predict the anticancer activity of a series of phthalocyanine derivati...
Open access
Research Article10.9734/irjpac/2025/v26i6962
Kadjo François Kassi, Jean Missa Ehouman, Mamadou Guy-Richard Koné, Lamoussa Ouattara, Georges Stephane Dembele & Nahossé Ziao·Chemical Science International Journal·2021
The work was undertaken as part of the Buruli ulcer control program. It is particularly about the determination of the lipophilicity of mycolactones A/B and C, infectious factors of Mycobacterium ulcerans, the agent of Buruli ulcer. The REKKER method and some free software such a...
Open access
Research Article10.9734/CSJI/2021/v30i130211