Ghareb M. Soliman

An Ion Pairing Approach to Enhance Oral Bioavailability of Alendronate

Basma N. AbdEl-Hamid, Ghareb M. Soliman, Mohamed A. Attia & Giovanni M. Pauletti · Journal of Scientific Research and Reports · 2014

Aim: Alendronate (AL) is a nitrogen-containing bisphosphonate drug that exhibits limited oral bioavailability due to predominantly hydrophilic molecular properties. To enhance oral absorption of this important osteoporosis drug, a novel ion-pairing strategy using the cationic pol...