Gholam Reza Mobini

Digoxin Inhibits Retinoblastoma through Suppressing a Non-canonical TGFβ Signaling Pathway

Maryam Sheikhzade, Abolfazl Akbari, Reza Karkhaneh, Fariba Ghassemi, Abdolrahim Sadeghi, Mahshid Shahrzad Kavakani, Gholam Reza Mobini, Masoumeh Mohebbi & Mansour Heidari · Journal of Advances in Medicine and Medical Research · 2016

Aims: Retinoblastoma is a childhood ocular tumor rapidly developing from the immature cells of the retina due to loss of functional retinoblastoma protein. Digoxin, a cardiac glycoside, has been reported to be effective in inducing apoptosis, cell cycle arrest, and cytotoxic effe...