Determination of pKa and Degradation Products of the Mutated BRAF Inhibitor Vemurafenib and UPLC Assay in Human Urine
Senem Şanli, Ayşe Özdemir, Gülşen Güven & Süleyman Gökçe · Journal of Pharmaceutical Research International · 2020
In this study, the pKa value of vemurafenib was determined by the dependence of the retention factor on the pH of the mobile phase. The change of pKa in the different acetonitrile fraction ranging between 57.5 and 62.5% (v/v) was studied by using an LC-UV method. Additionally, a...
Open access
Research Article
10.9734/jpri/2020/v32i3630986