Facile Synthesis of a Cholesterol–Doxorubicin Conjugate Using Cholesteryl-4-nitrophenolate as an Activated Ester and Biological Property Analysis
Pedro Freitas, Dina Maciel, Jolanta Jaśkowska, Kamila Zeńczak-Tomera, Yanbiao Zhou, Guoyin Yin & Ruilong Sheng · Organics · 2025
Developing new biomolecule–drug conjugates as prodrugs is a promising area for natural products and pharmaceutical chemistry. Herein, a cholesterol–doxorubicin (Chol-DOX) conjugate was synthesized using cholesteryl-4-nitrophenolate as a facile, stable, and controllable activated...
Open access
Research Article
10.3390/org6010006