Hassan Sadek Darwish

Bioinformatics Analysis of LDLR Gene Mutation that Shed a New Light on Red Yeast Rice Monacolin K Treatment – Systematic Review

Hassan Sadek Darwish, Hajer Almamri, Ray Barazie & Mohammed Mustafa · Annual Research & Review in Biology · 2022

Background: Hypercholesteremia is the major cause of cardiovascular diseases. It results from elevated cholesterol levels in the blood. LDL cholesterol is removed from the circulation by using the LDL receptor. Red mold rice or red yeast rice is produced by fermentation of the Mo...

Open access Research Article 10.9734/arrb/2022/v37i730521

The Effects MTHFR Gene Mutations on Vitamin B12 Concentration in the Blood; Bioinformatics Approach – A Review

Hassan Sadek Darwish, Sara Maram Khan, Jamal Badshah, Jomana Hussein, Shahad Almshlib & Wasan Abdelkarim · Journal of Advances in Medical and Pharmaceutical Sciences · 2021

Introduction: The protein encoded by MTHFR gene catalyzes the conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular dis...

Open access Research Article 10.9734/jamps/2021/v23i1130267

Association between a SLC23A2 Gene Variation, Plasma Vitamin C Levels, and Risk of Different Diseases

Hassan Sadek Darwish, Amal Al-Ghammari, Fatma Al-Amrani, Khaloud Al-Saadi, Munira Al-Hatmi, Najla Al-Hasani & Tasneem Al-Khusaibi · Journal of Advances in Medical and Pharmaceutical Sciences · 2021

Background: Vitamin C is an important plasma water-soluble antioxidant that plays an essential role in the absorption of iron, detoxification of exogenous compounds, and remaking vitamin E for the protection of lipid membranes. In addition, vitamin C is essential in the synthesis...

Open access Research Article 10.9734/jamps/2021/v23i1030262