Ibrahim KEITA

PfDHFR Resistance Mutations in Mali: Impact on Protein Structure and Identification of Novel Natural Inhibitors

Cheickna Cissé, Oudou DIABATE, Fatoumata Gnine FOFANA, Ibrahim KEITA, Seydou Doumbia, Ousmane KOITA & Mamadou WELE · Biotechnology Journal International · 2025

Malaria drug resistance remains one of the greatest challenges to the malaria control program in Mali. Mutation in the Plasmodium falciparum Dihydrofolate Reductase (PfDHFR), a key enzyme in the folate biosynthesis pathway and primary target of antifolate drugs, are knows to indu...