Introduction: Periodontal disease is an infection of the tissues that hold your teeth in place. It's typically caused by poor brushing and flossing habits that allow plaque, a sticky film of bacteria, to build up on the teeth and harden. Elimination of these pathogens from the si...
Open access
Research Article10.9734/jpri/2021/v33i47B33166
Introduction: Triclosan is considered to be an important ingredient in toothpastes and mouth rinses. Several studies have reported contradictory results regarding the antimicrobial effect of triclosan. Hence, the present in silico study intends to identify the potential targets o...
Open access
Research Article10.9734/jpri/2021/v33i47B33169
Introduction: HNSCC is a type of cancer in the oral and pharynx region. Several mutations/variations are observed in these cancer phenotypes. Fibroblast growth factor belongs to the family of heparin binding growth factors. FGFs are multifunctional proteins with a wide variety of...
Open access
Research Article10.9734/jpri/2021/v33i47B33172
Introduction: Head and neck squamous cell carcinoma (HNSCC) is an aggressive life-threatening disease associated with high mortality rates. Several genes related to stress response have been studied extensively to reveal their possible association with HNSCC. Members of the HSPA...
Open access
Research Article10.9734/jpri/2021/v33i47B33136
Background: Antimicrobial drug resistance is the major problem encountered world-wide. Novel therapeutic leads have been identified and are regularly tested for their activity against microbial pathogens. Aim: To identify the protein network interactions of triclosan in red compl...
Open access
Research Article10.9734/jpri/2021/v33i47B33137
Deducing the molecular pathway underlying the antimicrobial effect of phytocompounds is an inevitable part of drug discovery. Selection of potential targets on the microbial pathogens will eventually lead to eradication of microbes and effective treatment. In this context, the pr...
Open access
Research Article10.9734/jpri/2020/v32i2130749
In this study, the functional and virulent classes of proteins that are targeted by ferulic acid are identified from the most common dental pathogens like Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Streptococcus mutans and Enterococcus faecalis by an in...
Open access
Research Article10.9734/jpri/2020/v32i1830684
The objective of the study was to detect the presence of fimH gene among the drug resistanst strains of Acinetobacter baumannii. fimH gene was found to be associated with a catch bond mechanism which led to better evolution of biofilm formation. Since there are not many studies d...
Open access
Research Article10.9734/jpri/2020/v32i1630644
Fluoroquinolones are administered as routine drugs of choice for treating complicated urinary tract infections caused by multidrug resistant Acinetobacter baumannii strains. It is now a world-wide issue that gyr and par induced quinolone resistance as one of the major drug resist...
Open access
Research Article10.9734/jpri/2020/v32i1630645
Evaluation of the drug ligand interactions between the C. cassia bio-compounds with the SAP-1 in C. albicans to explore the inhibitory medicinal potential of C. cassia bio-compounds by a computational approach is performed in the present investigation. Antimicrobial assay was don...
Open access
Research Article10.9734/jpri/2020/v32i1630651
Glycyrrhizin is a phytocompound which is derived from Glycyrrhiza glabra. It is used in treating the upper respiratory tract disease like cough, bronchitis, laryngitis, sore throat, etc. It has various medicinal uses in rheumatism, peptic ulcers, asthma, allergies, and inflammati...
Open access
Research Article10.9734/jpri/2020/v32i1530640
Background: Acinetobacter baumannii is a gram negative non-motile coccobacillus, which was considered as a low priority pathogen with low virulence. Recently, it was declared as the priority pathogen under the critical category of the most dangerous pathogen by WHO. Acinetobacter...
Open access
Research Article10.9734/jpri/2021/v33i47B33156
The aim of this study is to identify the genetic alteration in SPARC gene family and its association with head and neck squamous cell carcinoma (HNSCC). Head and neck cancer is a set of cancerous lesions arising from the squamous cell of the mucous membrane of the oral cavity, no...
Open access
Research Article10.9734/jpri/2020/v32i2730861
Derailments in signal transduction pathways are associated with the development of tumors. One such vital pathway is the Notch signaling pathway which is associated with various processes of carcinogenesis such as proliferation of cells, cell renewal, angiogenesis and oncogenic m...
Open access
Research Article10.9734/jpri/2020/v32i2030732
Head and neck squamous cell carcinoma (HNSCC) is the most common form of cancer with an incidence rate greater in male than in female. Advancements in molecular diagnostics have identified several pathways which can have a direct or indirect role in the development and progressio...
Open access
Research Article10.9734/jpri/2020/v32i2030733
The cell suicide pathway of apoptosis is a necessary event in the life of multicellular organisms. It is involved in many biological processes ranging from development to the immune response. Over expression of interleukin-1β-converting enzyme (later renamed caspase-1) was shown...
Open access
Research Article10.9734/jpri/2020/v32i1530629
Head and neck squamous cell carcinoma (HNSCC) includes carcinomas in the oral cavity, pharynx and larynx. It is considered as the sixth most common form of cancer in the world. Several studies have confirmed that smoking and alcohol consumption are the major risk factors for HNSC...
Open access
Research Article10.9734/jpri/2020/v32i1530639