1,5-Acrylodan: A Fluorescent Bioconjugate Sensor of Protic Environments
Jake Morrin, Matthew Petitt & Christopher Abelt · Organics · 2024
1,5-Acrylodan (1-(5-(dimethylamino)naphthalen-1-yl)prop-2-en-1-one) is prepared in six steps from 1-nitronaphthalene and 19% overall yield. The last three steps involve an aryllithium-directed nucleophilic addition, catalytic Kulinkovich cyclopropanation, and copper-catalyzed oxi...
Open access
Research Article
10.3390/org5040026