K. F. A. Soliman

High-Throughput Screening to Identify Plant Derived Human LDH-A Inhibitors

S. Deiab, E. Mazzio, S. Messeha, N. Mack & K. F. A. Soliman · European Journal of Medicinal Plants · 2013

Aims: Lactate dehydrogenase (LDH)-A is highly expressed in diverse human malignant tumors, parallel to aggressive metastatic disease, resistance to radiation /chemotherapy and clinically poor outcome. Although this enzyme constitutes a plausible target in treatment of advanced ca...

Research Article 10.9734/EJMP/2013/5995

The Role of Monocarboxylate Transporters and Their Chaperone CD147 in Lactate Efflux Inhibition and the Anticancer Effects of Terminalia chebula in Neuroblastoma Cell Line N2-A

S. S. Messeha, N. O. Zarmouh, E. Taka, S. G. Gendy, G. R. Shokry, M. G. Kolta & K. F. A. Soliman · European Journal of Medicinal Plants · 2016

Aims: In the presence of oxygen, most of the synthesized pyruvate during glycolysis in the cancer cell of solid tumors is released away from the mitochondria to form lactate (Warburg Effect). To maintain cell homeostasis, lactate is transported across the cell membrane by monocar...

Open access Research Article 10.9734/EJMP/2016/23992