Livia Basile

Rescuing Abandoned Molecules as Nav1.7 and PCSK9 Inhibitors

Giuseppe Amico, Livia Basile, Giuseppe Romeo, Loredana Salerno, Maria N. Modica, Maria A. Siracusa, Agostino Marrazzo, Valeria Pittalà & Salvatore Guccione · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Academic institutions have plentiful of unexploited compounds. A cost-effective repositioning strategy from abandoned molecules coming from different research projects was applied. This strategy was based on the creation of a 2D-database then the biological assaying following adh...

Open access Research Article 10.9734/JAMPS/2016/22023

5HT1a Receptor Binding Affinities of a Series of Serotonin Transporter (SERT) Inhibitors and Related Thermodynamic Insights^

Gisella E. Alfonsino, Andrea Santagati, Livia Basile, Ettore Novellino, Corey Gaul, Carley Squires, Michael Braden, John M. Gerdes, Silvia Pérez Silanes, Salvatore Guccione & Keith K. Parker · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Clinical depression encompasses a complex neurobiology involving multiple interacting systems. This intricate pathophysiology is, in part, correlated with dysfunction in serotonin (5HT) neurochemistry. The 5HT1a receptor (R) and SERT (serotonin transporter) components of this net...

Open access Research Article 10.9734/JAMPS/2015/18917