This research describes the synthesis and spectral analysis of new N-substituted nalidixic acid hydrazide derivatives. New compounds were obtained by the substitution reaction of nalidixic acid hydrazide with trisubstituted s-triazines. The structure of all synthesized compounds...
Open access
Research Article10.9734/ACSJ/2016/23144
This article presents synthesis of 2,4,6-trisubstituted-1,3,5-triazine derivatives. New compounds were obtained by sequential nucleophilic substitution of chlorine atoms in cyanuric chloride. Structure of all synthesized compounds was confirmed by spectral and elemental analysis....
Open access
Research Article10.9734/IRJPAC/2015/20466
Nalidixic acid was the first quinolone antibiotic introduced to the treatment of urinary tract infections. It was effective especially against Gram-positive and Gram-negative bacteria but resistance to it emerged rapidly. In this article we reviewed the newly synthesized nalidixi...
Open access
Research Article10.9734/IRJPAC/2015/17634
The reaction of hydrazides of carboxylic acids with aldehydes is an efficient synthetic method to produce N-substituted hydrazone derivatives. The resulting hydrazone compounds are considered as convenient intermediates and can be used to obtain new interesting heterocyclic syste...
Open access
Research Article10.9734/ACSJ/2015/16728
This study presents the synthesis, spectral analysis and in vitro antimicrobial evaluation of a new series of Schiff bases of 1,3,4-thiadiazole and 1,2,4-triazole (1-10). The structure of obtained compounds was confirmed by spectral analysis (IR, 1H NMR and 13C NMR) and elemental...
Open access
Research Article10.9734/IRJPAC/2015/16459
In this paper a new series of 1,3,4-thiadiazole derivatives have been designed, synthesized and evaluated as antimicrobial agents. New compounds were prepared by the reaction of 5-amino-1,3,4-thiadiazole-2(3H)-thione with appropriate aldehydes. The structures of the obtained comp...
Open access
Research Article10.9734/ACSJ/2015/16229