Thrombo-Haemorheological Coupling in Haemoglobinopathies: Mechanistic Insights into the Bidirectional Interplay between Coagulation Activation and Erythrocyte Flow Properties
Adenuga Jacob Olaitan, Olusegun Taiwo Oke, Muhibi Musa Abidemi, Adesina Beatrice Ebun, Olatunji Oluwatobi, Ajao Oluwadare Amos & M. B. Ajayi · International Blood Research & Reviews · 2026
Hemoglobinopathies (e.g., HbS, HbC, HbF) are the most common single-gene disorders worldwide, especially in sub-Saharan Africa. Beyond affecting red blood cells and oxygen transport, they significantly disrupt blood clotting (hemostasis) and blood flow properties (haemorheology)....