Investigation of the H3PO4-Promoted Reaction of Benzaldehydes, Ethyl Acetoacetate or Ethyl Cyanoacetate or Malononitrile in the Presence of Urea as a Route to Pyrimidin-2-ones and 2-Iminochromenes
Ishmael B. Masesane, Ngonye Keroletswe & Runner R. Majinda · International Research Journal of Pure and Applied Chemistry · 2015
The H3PO4-promoted reactions of benzaldehydes, active methylene compounds and urea are reported. Benzaldehydes, ethyl acetoacetate and urea react in the presence of H3PO4 to give substituted pyrimidin-2-ones in 49-84% yields. The three-component reaction failed when either ethyl...
Open access
Research Article
10.9734/IRJPAC/2015/20189