Nikos C. Papandreou

Optimizing the Aggregation Propensity of Therapeutic Monoclonal Antibodies against Cancer and Autoimmune Diseases: A Computational Study

Anna-Isavella G. Rerra, Vasiliki P. Grimanelli, Nikos C. Papandreou & Stavros J. Hamodrakas · International Journal of Biochemistry Research & Review · 2016

Monoclonal antibodies (mAbs) represent the most promising and rapidly growing class of therapeutic compounds for treating a wide variety of human chronic and acute diseases.  Despite their benefits, a major drawback in the exploitation of antibodies is their tendency to form aggr...