Beyond Dosage Compensation: Re-evaluating the Lyon Hypothesis in X-chromosome Reactivation, Meiotic Fidelity, and Female Fertility
Edafe Gift Daniel, Odokuma Emmanuel Igho & Obue Ovoke Favour · Asian Journal of Medical Principles and Clinical Practice · 2026
The Lyon hypothesis established the classical framework for understanding X-chromosome inactivation as a dosage-compensation mechanism in female mammals. However, recent advances in molecular and cellular biology indicate that X-chromosome regulation during germ-cell development...