Onyinyechukwu A. R. Ayabazu

Early-Onset Type 1 Diabetes Mellitus in Children: A Critical Review of Pathogenesis, Epidemiology, Clinical Management, and Emerging Therapeutic Strategies

Onyinyechukwu A. R. Ayabazu & Obinna D. Nwaizuzu · Asian Journal of Research and Reports in Endocrinology · 2026

Early-onset type 1 diabetes mellitus (T1DM) in children is one of the most prevalent and clinically complex chronic autoimmune diseases of childhood, defined by progressive immune-mediated destruction of pancreatic beta cells, absolute insulin deficiency, and lifelong management...