Raymond Kre N’guessan

In silico Design of Sulfenylated 5-Aminopyrazole Derivatives, Novel Butyrylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease

Issouf Soro, Manchondenin Soro, Ludovic Akonan, Niaré Adama, Boris Davy Bekono, Raymond Kre N’guessan & Eugene Megnassan · Asian Journal of Chemical Sciences · 2026

Alzheimer’s disease (AD) is a neurodegenerative disorder associated with cholinergic dysfunction, and butyrylcholinesterase (BuChE) becomes increasingly relevant as disease pathology progresses. This study aimed to design sulfenylated 5-aminopyrazole (APS) analogues as potential...