Songuigama Coulibaly

Pharmacochemical Evolution of Carbapenems and Structural Analogues

Songuigama Coulibaly, Jean-Paul D.U. N'guessan, Apleheni E.M. Adouko, Jean-Fabrice K. Koffi, Lise A Koffi & Mahama Ouattara · Chemical Science International Journal · 2025

Carbapenems are a major class of antibiotics with a β-lactam nucleus that are distinguished by their effectiveness against many resistant pathogens. The discovery of Thienamycin, from Streptomyces cattleya, was the starting point for these antibiotics that revolutionized the trea...

Open access Research Article 10.9734/CSJI/2025/v34i1944

New Biological Targets in Fungi and Novel Molecule under Development: A Review

Songuigama Coulibaly, Jean-Paul D. U. N'guessan, Alain Kacou, Jean-Fabrice K. Koffi, Amelanh S. Diakité, Tanguy K. A. Kouaho & Mahama Ouattara · Chemical Science International Journal · 2021

Antifungal therapeutics is confronted today with the challenge of drug resistance of most fungal germs to current antifungal drugs. Faced with this situation, the search for new and more efficient antifungal molecules that avoid the phenomenon of drug resistance becomes an urgent...

Open access Research Article 10.9734/CSJI/2021/v30i630235

Synthesis, Antifungal Evaluation, and Structure–activity Relationship of Chlorinated Imidazopyridinyl- phenylpropenone Derivatives against Aspergillus fumigatus

Deto Ursul Jean-Paul N’guessan, Songuigama Coulibaly, Avi Tanguy Kouao, Alain A. Kacou, Kpongbo Etienne Angora, Fabrice Koffi, Ismaila Diallo & Mahama Ouattara · Chemical Science International Journal · 2025

Background: Aspergillus fumigatus is the leading causative agent of invasive aspergillosis, a deadly opportunistic fungal infection in immunocompromised patients. The increasing emergence of azole-resistant strains necessitates the urgent development of new antifungal molecules....

Open access Research Article 10.9734/CSJI/2025/v34i61011

Synthesis and Anticandidal Activity of New 6-Chloroimidazo[1,2-a]pyridine Derivatives

Deto Ursul Jean-Paul N’guessan, Songuigama Coulibaly, Alain A. Kacou, Kpongbo Etienne Angora, Fabrice Koffi & Mahama Ouattara · Asian Journal of Chemical Sciences · 2025

Aims: The general objective assigned to this work was to contribute to the pharmacochemical development of new antifungal drugs derived from 6-Chloroimidazo [1,2-a]pyridine.This preliminary study was conducted on Candida parapsilosis, which is an increasingly difficult organism t...

Open access Research Article 10.9734/ajocs/2025/v15i3371