Differential Regulation of E-Cadherin Expression by the Soluble Ectodomain and Intracellular Domain of Jagged1
Craig Delury, Claire Tinker, Samantha Rivers, Matthew Hodges, Susan Broughton & Edward Parkin · International Journal of Biochemistry Research & Review · 2013
Aberrant Jagged1-mediated Notch activation is linked to cancer and induces epithelial-to-mesenchymal transition through the repression of E-cadherin transcription. All three proteins are subject to sequential proteolytic events referred to as regulated intramembrane proteolysis....
Open access
Research Article
10.9734/IJBCRR/2013/3847