Tahar Lakhlifi

3D-QSAR Modeling and Molecular Docking Studies on a Series of 1,2,4 Triazole Containing Diarylpyrazolyl Carboxamide as CB1 Cannabinoid Receptor Ligand

Adib Ghaleb, Adnane Aouidate, Mounir Ghamali, Abdelouahid Sbai, Mohammed Bouachrine & Tahar Lakhlifi · International Research Journal of Pure and Applied Chemistry · 2017

3D-QSAR (CoMFA and CoMSIA) and Surflex-docking studies were employed on a series of triazole as CB1 cannabinoid receptor ligand as anti-obesity agents. The CoMFA and CoMSIA models using 20 compounds in the training set gave Q2 values of 0.9 and 0.93, and r2 values of 0.98 and 0.9...