Unveiling Novel KRAS G12V Inhibitors: A Comprehensive Study Using Computer-aided Drug Design Approach
Amena Khatun Manica, Benedicta Quainoo, Jonathan Cudjoe, Aminat Motunrayo Adekunle, Cyril Agadagba, Temilade Rukayat Adeniran, Oluwatosin Oluwafunmilola Oluwafemi, Ayomide Daniel Oluwafemi, Abasiodiong Ekanem, Hikmat Opeyemi Sulaiman, Farimah Mohammadi, Emmanuel Parkay Oladokun, Mariam Omowunmi Oguntunji & Roheemah Olamide Oni · International Journal of Biochemistry Research & Review · 2025
The KRAS G12V mutation is a formidable oncogenic driver implicated in the pathogenesis of several aggressive cancers, including pancreatic ductal adenocarcinoma, non-small cell lung cancer, and colorectal cancer. Overcoming the historical challenges associated with targeting KRAS...