Yasmim Batista de Paiva

Molecular Pathogenesis and Targeted Therapeutic Advances in Langerhans Cell Histiocytosis: A Systematic Review

Roger Antonio Morais Queiroz, Gabriela Aguiar Rezende, Ismael de Sousa Armondes, Joaquim Alberto Lopes Ferreira Junior, João Protásio Netto, Fernando Macena Lino, Yasmim Batista de Paiva, Cássio Luis Tavares Dias, Vagner Carmargo Pires & Regina de Fátima Mendes Onofre · Advances in Research · 2026

Introduction: Langerhans Cell Histiocytosis (LCH) is a rare myeloid neoplasm characterized by clonal proliferation of immature dendritic cells, primarily driven by constitutive activation of the MAPK signaling pathway through mutations in BRAFV600E, MAP2K1, and ARAF. Recent genom...