A Study of the Protective Role of Berberis vulgaris Aqueous Extract on Some Liver Enzymes and Proteins in Male Rats Treated with Monosodium Glutamate

Abstract

Various civilizations utilize the fruit of the common herb barberry as a culinary component. Barberry is utilized as a therapeutic herb. This is used in traditional medicine for gastrointestinal issues, kidney stones, gallbladder and liver issues, circulatory system stimulation, and urinary tract abnormalities. Twenty adult male rats, ages 2-4 months, with an average weight of 150-300 g, have been utilized in the study. The rats have been split up to four groups (G), with five rabbits in each one of the groups. G1 was treated with normal saline extract 15 ml orally as the positive control group, G2 was treated with aqueous extract 14 mg/kg as the negative control group, G3 was treated with aqueous extract of Berberis vulgaris (300 mg/kg BW), and G4 was treated with aqueous extract of Berberis vulgaris (300 mg/kg BW) following 3hours. This study sought to ascertain protective effect of Berberis vulgaris extract on albumin, total protein, aspartate amino transaminase (ALT), globulin, alkaline phosphate (ALP), and alanine amino transaminase (AST). The current study's findings indicated that the mean levels of ALT, AST, ALP, albumin, total protein, and globulin have been much higher (p≤0.050) in G2 group than in G1 group. We have found no significant difference (p≥0.050) in levels of ALT, AST, total protein, ALP, albumin, and globulin in the group that had received doses of Berberis vulgaris (300 mg/kg BW) and Monosodium glutamate (14 mg/kg BW) in comparison with G1. We found a significant decrease (p≤0.050) in levels of (ALP, ALT, and AST) total protein, globulin, and albumin in G4 and G3 in comparison with G2. The study demonstrated that common barberry significantly enhances protective functions through the elevation of liver enzyme and protein levels. The observed effects are ascribed to the direct influence of the plant extract on hepatic function.