Patient Preferences for the Mode and Frequency of Drug Formulations for Treating Adults with Psoriatic Arthritis: A Systematic Review Protocol

Abstract

Background: Psoriatic Arthritis (PsA), affects diverse patient populations with different levels of disease severity and associated comorbidities. Patients with psoriatic arthritis and their relatives may prefer and demand certain medications in use and how often they are administered by the physician. Understanding patients’ perspectives and involving them in healthcare decision-making influence medication adherence and treatment outcomes. Objectives: This systematic review aims to synthesize evidence from discrete choice experiments that elicit patients’ preferences for the mode and frequency of administration of biological agents used for treating psoriatic arthritis in adults, as well as the relationship between these preferences and patient characteristics. Data Sources: Electronic databases including Web of Science, PubMed, Scopus, Embase, PsycINFO, and ECONLIT will be searched for relevant articles written in English. These electronic sources of information were chosen because of the wider indexing of scholarly articles. Grey literature search and scanning of the reference list of included studies for potentially relevant papers will also be performed. Study Eligibility and Criteria: Peer-reviewed articles that have employed discrete-choice experiments and methods such as conjoint analysis to assess patients’ preferences for mode and frequency of administration of therapies used for treating PsA in adults greater > than 18 years (correction: greater than 18 years) of age will be included. Eligible studies must be published in English. Study Appraisal and Synthesis Methods: Two reviewers will independently screen the studies against predetermined inclusion criteria at the title, abstract, and full-text levels. The quality assessment will be conducted using the PREFS Checklist (Purpose, Respondents, Explanation, Findings, and Significance) to examine the quality of the included articles. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension (PRISMA-P) 2015 was followed in developing the review protocol. This protocol has been registered in the PROSPERO database (#CRD42023439635).