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Research Article Open access CC BY 4.0

Thia-Michael Reaction under Heterogeneous Catalysis

Giovanna Bosica, Roderick Abdilla, Alessio Petrellini

Organics · pp. 86–96 · Published 21 Feb 2023

10.3390/org4010007

Abstract

Thia-Michael reactions between aliphatic and aromatic thiols and various Michael acceptors were performed under environmentally-friendly solvent-free conditions using Amberlyst® A21 as a recyclable heterogeneous catalyst to efficiently obtain the corresponding adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylamide, linear, and cyclic enones were also utilized successfully. Bifunctional Michael donor, 3-mercaptopropanoic acid, positively furnished the product, albeit in a lower yield and after leaving the reaction to take place for a longer time. The catalyst was easy and safe to handle and successfully recycled for five consecutive cycles.

Michael reaction Bifunctional Catalysis Chemistry Yield (engineering) Adduct Environmentally friendly Organic chemistry

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Cited by 6

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