25 (OH) Vitamin D level and Calcium/Phosphorus Metabolism Disorders in Patients Living with HIV  in Abidjan

Lydie Boyvin; Jeanne Armande Aké; Kipré Laurent Séri; Gervais Melaine M’boh; Adou Francis Yapo; Joseph Allico Djaman

doi:10.9734/IJBCRR/2017/34351

Research Article Open access CC BY 4.0

25 (OH) Vitamin D level and Calcium/Phosphorus Metabolism Disorders in Patients Living with HIV in Abidjan

Lydie Boyvin, Jeanne Armande Aké, Kipré Laurent Séri, Gervais Melaine M’boh, Adou Francis Yapo, Joseph Allico Djaman

International Journal of Biochemistry Research & Review · pp. 1–7 · Published 17 Jun 2017

10.9734/IJBCRR/2017/34351

Abstract

Aims: The present study was to evaluate the serum calcium level, phosphorus and 25 (OH) vitamin D subjects during HIV infection; precisely in patients living with HIV (PLHIV). Study Design: Prospective and experimental study, involving a cohort of blood samples from HIV-negative and positive subjects. Place and Duration: The study was carried out in the clinical and fundamental biochemistry Department of the Institut Pasteur of Côte d’Ivoire from June 2014 to December 2014. Methodology: A cohort of 220 samples from adult blood samples, comprising of 110 HIV negative controls and 110 samples from PLHIV subjects, were analyzed. After confirmation of HIV status (through an HIV rapid test) of subjects, CD4 lymphocytes were measured through flow cytometry analysis using an automated FacsCaliburTM. Analysis of calcium and phosphorus electrolytes was performed on the Cobas Integra 400 Plus and 25 (OH) vitamin D on the automated mini VIDAS, from the sera obtained from different blood samples from HIV positive and negative subjects. Results: The identified disorders in the PLHIV were hypocalcemia (P = 0.0009) and hyperphosphoremia (p < 0.0001). 57% of PLHIV against 67% of the control subjects showed normal levels of 25 (OH) vitamin D (P > 0.05). Conclusion: We noticed a good level of 25 (OH) Vitamin D reserve in PLHIV among more than 50% of PLHIV. Calcium and Phosphorous metabolism disorders observed in people living with HIV in Côte d'Ivoire are due to a deficiency of the active form 1,25 (OH)2 vitamin D.

25 (OH) Vitamin D calcium Côte d’Ivoire HIV phosphorus

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Lydie Boyvin, Jeanne Armande Aké, Kipré Laurent Séri, Gervais Melaine M’boh, Adou Francis Yapo, Joseph Allico Djaman (2017). 25 (OH) Vitamin D level and Calcium/Phosphorus Metabolism Disorders in Patients Living with HIV in Abidjan. International Journal of Biochemistry Research & Review , 1–7. https://doi.org/10.9734/IJBCRR/2017/34351

Affiliations

Lydie Boyvin — Department of Clinical and Fundamental Biochemistry, Institut Pasteur of Cote d’Ivoire (IPCI), 01 BP 490, Abidjan 01, Côte d’Ivoire and Pharmacodynamics Laboratory of Biochemical, University Félix Houphouët-Boigny (UFHB), 01 BP V34, Abidjan 01, Côte d’Ivoire
Jeanne Armande Aké — Department of Clinical and Fundamental Biochemistry, Institut Pasteur of Cote d’Ivoire (IPCI), 01 BP 490, Abidjan 01, Côte d’Ivoire and Pharmacodynamics Laboratory of Biochemical, University Félix Houphouët-Boigny (UFHB), 01 BP V34, Abidjan 01, Côte d’Ivoire
Kipré Laurent Séri — Department of Clinical and Fundamental Biochemistry, Institut Pasteur of Cote d’Ivoire (IPCI), 01 BP 490, Abidjan 01, Côte d’Ivoire and Pharmacodynamics Laboratory of Biochemical, University Félix Houphouët-Boigny (UFHB), 01 BP V34, Abidjan 01, Côte d’Ivoire
Gervais Melaine M’boh — Pharmacodynamics Laboratory of Biochemical, University Félix Houphouët-Boigny (UFHB), 01 BP V34, Abidjan 01, Côte d’Ivoire
Adou Francis Yapo — Pharmacodynamics Laboratory of Biochemical, University Félix Houphouët-Boigny (UFHB), 01 BP V34, Abidjan 01, Côte d’Ivoire
Joseph Allico Djaman — Department of Clinical and Fundamental Biochemistry, Institut Pasteur of Cote d’Ivoire (IPCI), 01 BP 490, Abidjan 01, Côte d’Ivoire and Pharmacodynamics Laboratory of Biochemical, University Félix Houphouët-Boigny (UFHB), 01 BP V34, Abidjan 01, Côte d’Ivoire

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