Structure and Function of COVID-19 Encode Proteins in the Transcription and Replication Mechanism with Its Preventive Measures and Propose Efficacy Treatments: A Critical Systematic Review

Abstract

The sudden occurrence outbreak of coronavirus disease in 2019 (COVID-19) by the severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) poses a serious harm worldwide and local economies. Due to high numbers of infection and death, the pandemic calls for an urgent demand of active, effective, affordable and available drugs to control and diminish the pandemic.  Coronavirus disease 2019 is a public health unexpected and sudden crisis which required action of international concern. At present there is no generally recognized effective pharmaceutical treatment to the disease, although it is to a great extent for patient contracting the severe form of the disease. The development of new strategies to prevent or control the spread of COVID-19 infections and the understanding of the virus replication, and pathogenesis required immediate action. Therefore, this systematic review was to investigate the biochemical effect of the virus in human, symptoms, prevention, statistics cases and summarize the evidence regarding chloroquine and hydroxychloroquine for the treatment of COVID-19.