Pharmacological Potential of Tricosanthes tricuspidata and Clematis montana for Hypoglycemic and Antioxidant Activity

Abstract

The aim of present study was to evaluate the antidiabetic and antioxidant potential of Tricosanthes tricuspidata and Clematis montana leaf and root extracts. On the basis of toxicity studies a dose of 200 mg/kg body weight was selected for antidiabetic activity. Diabetes was induced by the administration of streptozotocin at a dose of 50 mg/kg, intra peritoneal. Among all the extracts, ethanolic extract (EtOH) of T. tricuspidata (197.5±1.31**) and C. montana (183.8±3.79**) have  shown significant reduction in blood glucose level in SZT induced diabetic Wister rats as compared to control and the standard drug glipizide (5 mg/kg body weight). Aqueous extract of T. tricuspidata (22.35%) and ethanolic extract of C. montana (26.23%) have shown significant antioxidant activity when compared with standard (Ascorbic acid & BHT) at 30 µg/ml concentration. The results of the study concluded that Tricosanthes tricuspidata and Clematis montana leaf and root extracts have potential antidiabetic and antioxidant properties.