Ameliorative Effects of Spirulina and Chamomile Aqueous Extract against Mice Bearing Ehrlich Solid Tumor Induced Apoptosis
Afaf El-Atrsh, Ehab Tousson, Eman E. Elnahas, Ahmed Massoud, Marwan Al-Zubaidi
Asian Oncology Research Journal · pp. 25–41 · Published 25 Oct 2019
Abstract
Aims: Cancer is caused by an imbalance in the rate of proliferation and apoptosis and the positive effect of anticancer therapy is taken into consideration when its ability to initiate apoptosis in cancer cells. In vivo; several experimental models established in experimental animals besides the Ehrlich solid tumor (EST), derived from the mouse breast adenocarcinoma. This study aims to determine the curative role of spirulina or/ and chamomile to acting effectively in inhibition of Ehrlich cells growth and tumor development, in addition to the therapeutic activity of spirulina and chamomile aqueous extract on Ehrlich tumor in the solid forms induced apoptosis in solid tumor. Study Design: A total of 80 mice were equally divided into eight groups (Group 1, Control group; Group 2, spirulina group; Group 3, Chamomile group; Group 4, spirulina and chamomile group; Group 5, Ehrlish solid tumor group; Group 6: Mice Ehrlish solid tumor treated orally with spirulina; Group 7, Mice Ehrlish solid tumor treated orally with chamomile; Group 8, Mice Ehrlish solid tumor treated orally with both spirulina and chamomile for 2 weeks). Results: In the current study; a significant decrease in tumour volume, an decrease in apoptotic P53, Bax and pro apoptotic Caspase 3 expressions and increased in Bcl2 expressions was detected after the treatment of EST with extract of chamomile and spirulina together and spirulina extract only as compared with the tumour volume of EST group. In conclusion, the present study demonstrated that the combination of spirulina and chamomile has a better effect than each of spirulina or chamomile alone against Ehrlich solid tumor in mice. Conclusion: Ehrlich solid tumor induced apoptosis by increased P53, Bax, Caspase 3 and decrease Bcl2; treatment of Ehrlich solid tumor with combination of spirulina and chamomile improved these alterations in apoptosis markers.
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