Proteomic Biomarker Discovery: Review of the Science and Its Challenges with Clinical Samples
T. Hussain, L. Scaife, V. Hodgkinson, J. P. Kneeshaw, M. Lind, P. Drew, L. Cawkwell
Journal of Advances in Medicine and Medical Research · pp. 1–33 · Published 14 Sep 2013
10.9734/BJMMR/2014/5268Abstract
Proteomics is a science that facilitates global analysis of protein expression, molecular interactions and functional states of protein in a cell, organ or organism under consideration. Protein at the molecular level represents the biological endpoint and therefore more suitable to assess cellular responses. Proteins biomarkers are routinely used in cancers for different purposes such as diagnosis, screening and predicting therapy responses. Proteomic science utilise both cell line models and clinical samples to make novel discoveries. Compared to cell lines, clinical samples provide more accurate representation of the tumour micro-environment, explore and identify stromal molecular targets. However, using clinical samples for biomarker discovery has its own challenges. In this review, we aim to provide clinicians an overview of the proteomic biomarker discovery pathway, examine the use of different clinical samples in proteomic research and highlight the limitations and challenges of using clinical samples with proteomic methods.
Cited by 1
1 citation reported by external sources — individual citing-article records aren't available to list yet.
Related research
- Diagnostic Modalities of Tuberculosis- Then and Now — shares topic coverage
- D-Dimer: A Primer Biomarker in COVID-19 — shares topic coverage
- Elevated Peripheral Blood IL-6 Levels: A Novel Biomarker for Assessing Inflammation and Exacerbation Risk in Pediatric Bronchial Asthma — shares topic coverage
- Reproductive & Biomarker Response to a Daily Dose of Instant Noodle Seasoning in Male Albino Rats (Rattus norvegicus) — shares topic coverage
- Impact of Certain Heavy Metals on Histology and Physiology of Fishes: Interpretative Study — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
1
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.