Evaluation of CNS Depressant, Antidiarrheal and Antipyretic Activities of Ethanolic Leaf Extract of Calophyllum inophyllum L. on Swiss Albino Mice
Seuly Akter, Md. Saddam Hossain, Md. Rubel Mia, Md. Shahid Sarwar
Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–9 · Published 11 Mar 2017
10.9734/JAMPS/2017/29994Abstract
Objective: The main objective of the present study was to evaluate the CNS depressant, antidiarrheal and antipyretic activities of ethanolic leaf extract of Calophyllum inophyllum L. Methods: In the present study CNS depressant activity of C. inophyllum was carried out using hole-cross, hole-board and open-field models in swiss albino mice whereas castor-oil induced diarrhea was used to evaluate antidiarrheal activity. The antipyretic activity was conducted by Brewer’s yeast-induced hyperthermia in mice. Results: The experimental result indicates that the ethanolic extract of C. inophyllum induced CNS depression significantly (p<0.05) in tested animals and the observed effect was dose dependent comparable to standard drug diazepam. The plant extract at the dose of 250 and 500 mg/kg body weight showed significant inhibition of 41.66% and 62.19% in castor oil-induced diarrheal method. In yeast-induced pyrexia, the plant extract displayed dose-dependent inhibition as compared to paracetamol. Conclusion: This study concludes that C. inophyllum leaf has significant CNS depressant, antidiarrheal and antipyretic activities which provide scientific support for its medicinal applications.
Cited by 1
Pooja Rawat, Pawan Kumar Singh, Vipin Kumar · Biomedicine & Pharmacotherapy · 2017
Related research
- Elucidation of Phytochemical and Pharmacological Nature of Methanolic Extract of Ixora cuneifolia — shares topic coverage
- Underlying Mechanisms of Anti-spasmodic, Antidiarrheal, Antioxidant and Acute Toxicity Assessments of Aqueous Extract of Mentha Suaveolens Ehrh and its Fourier Transform Infra-red Spectroscopy Analysis — shares topic coverage
- Investigating the Bioactive Potential of Persicaria hydropiper: GC-MS Profiling and In vivo Exploration of Antinociceptive and Antidiarrheal Effects — shares topic coverage
- Pharmacological Study of Medicinal Plant Calophyllum inophyllum L. on Swiss Albino Mice in the Management of Pain and Inflammation — shares topic coverage
- Antioxidant and Antibacterial Activity of Field Grown and Tissue Cultured Root Callus of Mangrove Species — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
1
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.