Ehrlich Solid Tumor Induced Injury and Toxicity in Liver and Kidney in Female Mice

Abstract

Background and Objective: Cancer can develop in any organ at any time; it is a cellular malignancy that causes a breakdown in normal cell-cycle regulation, leading to unchecked proliferation and a lack of differentiation. It is the main factor in human mortality. The therapeutic efficacy of currently available drugs is minimal, and they do not prevent the growth of cancer. Current work aimed to study the effect of Ehrlich solid tumor (EST) on liver and kidney in female mice. Materials and Methods: Twenty mice were randomly and equally divided into two groups and each group consists of 10 mice; 1st group is control group in which mice did not receive any treatment and 2nd group is EST group, including mice, each mouse were injected subcutaneously with 2.5-3×106 EAC cells. Results: Current results revealed that; EST induced significant increase in the levels of serum urea, creatinine, potassium, chloride, aspartate transaminase (AST) and alanine transaminase (ALT) activities and alkaline phosphatase (ALP), kidney and liver injuries and cconversely, a significant decrease in sodium, calcium as associated to control. Conclusion: Current results indicated that EST induced damage and toxicity in liver and kidney.