Alteration of Serum Liver Enzymes Level Caused by Cetirizine Hydrochloride in Exercise Performers

Abstract

Background: Players regularly use cetirizine HCL for the prevention and treatment of various symptoms of allergy while playing in unfamiliar environments.    Objective: This research study was carried out to examine the effect of cetirizine HCL on liver function (ALT, ALP and AST) among the players. Methods: A descriptive study was carried out at Gomal University, Dera Ismail Khan from January 2019 to June 2019.Twenty male subjects 10 players using cetirizine HCL (one tablet of 10mg/day) as experimental group and 10 players not using cetirizine HCL as control group was selected voluntarily as participants of the study. Five ml blood was taken from all subjects after three hours of administration of cetirizine HCL for the assessment of ALT, ALP and AST.  The results obtained through liver functions test (LFTs) were analyzed through a statistical package for social sciences (SPSS, Version 24). Results: Significant difference was found in both groups (CG and EXG) in term of ALT (P = 000, 0.05>.000). There was significant difference between in both groups (CG and EXG) in term of ALP (P = 000, 0.05>.000). A significant difference was found between in both groups (CG and EXG) in term of AST (P = .001, 0.05>.000). Conclusion:  on the basis of finding, the researcher concluded that Cetirizine HCL (Tablet 10mg) produced a significant rise in liver enzymes and hence disturbing the normal functioning of liver.