Anxiolytic Effect of Citrus paradisi var. Marsh seedless Using Different Models
Vikas Gupta, Parveen Bansal, Kamlesh Kohli, Pankaj Ghaiye
International Neuropsychiatric Disease Journal · pp. 108–113 · Published 19 Jun 2015
10.9734/INDJ/2015/18699Abstract
Aims: The present study was designed to evaluate the anti-anxiety activity of various extracts of the leaves of Citrus paradisi var. Marsh seedless using light dark model and hole board methods in Swiss albino mice. Methodology: Swiss Albino mice were treated with different doses of the extracts (50,100,200 and 400 mg/kg p.o.) and Diazepam (2 mg/kg, p.o) was used as a positive control using Hole Board test and light dark model. Results: Results showed that methanol extract in doses of 100 mg/kg p.o. and 200 mg/kg p.o. possesses marked anti anxiety activity. This effect was comparable to the effect produced by standard drug, diazepam. Conclusion: Hence this plant may be developed as a potentially useful anxiolytic agent. Further studies are going on to find out the active constituent responsible for this activity.
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