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Research Article Open access CC BY 4.0

Synthesis, Characterization and Antimicrobial Activity of Some New Heterocyclic Compounds Incorporating Pyridazine Moiety

Fekria M. A. Soliman, Nadia T. A. Dawoud, Nahed F. Abdel-Ghaffar, Marwa I. El-Guindy, Heba Naguib

Chemical Science International Journal · pp. 1–14 · Published 12 Feb 2016

10.9734/ACSJ/2016/23961

Abstract

A series of heterocyclic compounds incorporating pyridazine moiety (1-24) were synthesized and evaluated for antimicrobial activities Gram- positive bacteria, Gram- negative bacteria and Yeast. Compounds 2b, 2c, 6, 7 and 10 were tested under antimicrobial activities as MICS. The results illustrated that among the synthesized compounds as a lead compound with good antimicrobial activity.

Pyridazine α,- unsaturated compounds antimicrobial activity

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