Synthesis, Biological Activity and Applications of 1,2,5-Oxadiazol:  A Brief Review

João Rufino de Freitas Filho; Jucleiton José Rufino de Freitas; Juliano Carlo Rufino de Freitas; Clécio de Souza Ramos; Fabrícia Aparecida Marques de Souza; Jaqueline Ferreira Ramos; Ricarte Tavares; Drielly Emanoele Tomé Barros de Oliveira

doi:10.9734/irjpac/2023/v24i1798

Research Article Open access CC BY 4.0

Synthesis, Biological Activity and Applications of 1,2,5-Oxadiazol: A Brief Review

João Rufino de Freitas Filho, Jucleiton José Rufino de Freitas, Juliano Carlo Rufino de Freitas, Clécio de Souza Ramos, Fabrícia Aparecida Marques de Souza, Jaqueline Ferreira Ramos, Ricarte Tavares, Drielly Emanoele Tomé Barros de Oliveira

International Research Journal of Pure and Applied Chemistry · pp. 1–26 · Published 5 Jan 2023

10.9734/irjpac/2023/v24i1798

Abstract

Oxadiazoles are heterocyclic compounds that belong azole class which contain two nitrogen atoms and one oxygen, forming a five-membered heterocyclic ring. Four isomers of oxadiazoles are described in the literature. Among these, 1,2,4-oxadiazole, 1,2,5-oxadiazole, and 1,3,4-oxadiazole have several applications biological. Compounds of this type have been used in the treatment of various diseases in both humans and animals.Among the immense class of heterocycle compounds with important biological activities already identified, the 1,2,5-oxadiazoles have stood out for the wide variety of applications in medicinal chemistry, in material, and agricultural chemistry. In this work, the main synthesis methods and advances for obtaining 1,2,5-oxadiazoles and their derivatives reported in the literature over the years are reviewed, as well as the applications of these compounds in several branches of chemistry and their biological activities discovered until the moment. GRAPHICAL ABSTRACT:

1,2,5-oxadiazoles biological activities medicinal chemistry NO donor

Cited by 5

Theoretical study of the molecular mechanism and regioselectivity of the (3+2) cycloaddition reaction between benzonitrile oxide and 2,4-dimethyl-2H-1,2,3-triazole and molecular docking studies of the obtained cycloadducts

Abderrahim El Haib, Yassine Hakmaoui, Fatima Asserne · Chemistry of Heterocyclic Compounds · 2025

Recent advances in the synthesis of pharmacologically active 1,2,3-, 1,2,4-, and 1,2,5-oxadiazole-based lead compounds

I. A. Stebletsova, A. A. Larin, L. L. Fershtat · Russian Chemical Reviews · 2025

A mild and efficient synthesis of aminofurazans

Aleksei B. Sheremetev, Andrei S. Kozeev, Nadezhda V. Palysaeva · New Journal of Chemistry · 2023

Synthetic Organic Molecules as Metallic Corrosion Inhibitors: General Aspects and Trends

Renato Corrêa da Silva Lessa · Organics · 2023

Showing 4 of 5 known citations — external sources report more than can currently be individually listed.

Production of Volatile Compounds by Lactococcus lactis sp. Strain at Different Growth Phases — shares topic coverage
Triterpenes and Triterpenoids Clinically Useful with Multiple Targets in Cancer, Malaria and More Treatment: Focus on Potential Therapeutic Value — shares topic coverage
Therapeutics Activities of Amazonian Plant Himatanthus sucuuba (Spruce ex Müll. Arg.) Woodson (Apocynaceae): A Review — shares topic coverage
Synthesis and Characterization of Se-doped ZnO Nanoparticles by Electrochemical Method: Photodegradation Kinetics of Indigo Carmine Dye and Study of Antimicrobial, Antimitotic Activities of Se-doped ZnO Nanoparticles — shares topic coverage
Ecofriendly Formulation and Biological Activities of Cosmetic Prepared from the Oil of Citrus paradisi and Citrus lemon Seeds — shares topic coverage

Access this article

View at publisher

Cite this article

João Rufino de Freitas Filho, Jucleiton José Rufino de Freitas, Juliano Carlo Rufino de Freitas, Clécio de Souza Ramos, Fabrícia Aparecida Marques de Souza, Jaqueline Ferreira Ramos, Ricarte Tavares, Drielly Emanoele Tomé Barros de Oliveira (2023). Synthesis, Biological Activity and Applications of 1,2,5-Oxadiazol: A Brief Review. International Research Journal of Pure and Applied Chemistry , 1–26. https://doi.org/10.9734/irjpac/2023/v24i1798

Affiliations

João Rufino de Freitas Filho — Programa de Pós-Graduação em Química, Universidade Federal Rural de Pernambuco, Dois Irmão, Recife, 52171-900, Pernambuco, Brazil.
Jucleiton José Rufino de Freitas — Universidade Federal Rural de Pernambuco, Cabo de Santo Agostinho, 54518-430, Pernambuco, Brazil.
Juliano Carlo Rufino de Freitas — Programa de Pós-Graduação em Química, Universidade Federal Rural de Pernambuco, Dois Irmão, Recife, 52171-900, Pernambuco, Brazil and Centro de Educação e Saúde, Universidade Federal de Campina Grande, Olho D’agua da Bica, s/n, Cuité, 58175-000 PB, Brazil.
Clécio de Souza Ramos — Programa de Pós-Graduação em Química, Universidade Federal Rural de Pernambuco, Dois Irmão, Recife, 52171-900, Pernambuco, Brazil.
Fabrícia Aparecida Marques de Souza — Programa de Pós-Graduação em Química, Universidade Federal Rural de Pernambuco, Dois Irmão, Recife, 52171-900, Pernambuco, Brazil.
Jaqueline Ferreira Ramos — Programa de Pós-Graduação em Química, Universidade Federal Rural de Pernambuco, Dois Irmão, Recife, 52171-900, Pernambuco, Brazil.
Ricarte Tavares — Programa de Pós-Graduação em Química, Universidade Federal Rural de Pernambuco, Dois Irmão, Recife, 52171-900, Pernambuco, Brazil.
Drielly Emanoele Tomé Barros de Oliveira — Programa de Pós-Graduação em Química, Universidade Federal Rural de Pernambuco, Dois Irmão, Recife, 52171-900, Pernambuco, Brazil.

Metrics

0
Views: 0
Downloads: 5
Citations: 0
Outbound

Full metrics

Article metrics

Real usage data collected on this platform.

0

Page views

0

PDF downloads

0

Outbound clicks

5

Citations

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

No views recorded yet.

Traffic sources

Referring site, by host.

No traffic recorded yet.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.