Skip to content
Research Article Open access CC BY 4.0

Calcium Oxalate Crystals as Raw Food Antinutrient: A Review

Justin R. Nayagam, Renu Rajan

Journal of Pharmaceutical Research International · pp. 295–301 · Published 24 Aug 2021

10.9734/jpri/2021/v33i41B32368

Abstract

The nutritional value of food can be altered by the presence of antinutrients such as oxalates present abundantly in plants as ergastic crystals. High oxalate content in plant-based raw food can lead to oxalonephropathy, nephrolithiasis and renal dysfunction. Presence of oxalate can hinder the absorption of other minerals such as calcium and magnesium present in food. CaOx antinutrient intake can be minimised by avoiding plant with high oxalate content or by decreasing oxalate levels through cooking practices like, boiling, fermenting, treating with baking soda, adding yoghurt and milk etc. More sophisticated ways of minimising antinutrient intake through raw diet is by choosing genetically modified crops which are bred for low oxalate content or by choosing mutant varieties which are devoid or low in oxalate content in food crops. The future for sustainable antinutrient management and nutritional value enhancement is by incorporating genes from bacteria or fungi which are capable of breaking down oxalate using the enzyme oxalate decarboxylase, on  to plants and thereby modifying them to have less antinutrient effects in raw consumption.

Calcium oxalate crystals ergastic crystals antinutrient raw food CaOx crystals nephrolithiasis

Cited by 9

Identification of glucomannan and oxalate content in the dasheen-type taro tuber (Colocasia esculenta var esculenta) during post harvest storage

D Maretta, D P Handayani, D Pinardi · IOP Conference Series: Earth and Environmental Science · 2025

OxDc-A0: an oral gastro-tolerant oxalate decarboxylase for treating secondary hyperoxaluria

Hai-feng Liu, Chun-yan Li, Yan-hong Liu · Urolithiasis · 2025

Formation of Unique Placental Seed Capsules in the Maturation Process of the Tomato Fruit

Inna A. Chaban, Alexander A. Gulevich, Ekaterina N. Baranova · International Journal of Molecular Sciences · 2022

Research progress on the formation, function, and impact of calcium oxalate crystals in plants

Hao He, Donghui Li, Xingxing Li · Crystallography Reviews · 2024

EKMEK ÜRÜNLERİNDE AKRİLAMİD OLUŞUMU ÜZERİNE DOĞAL ANTİOKSİDANLARIN ETKİSİ: MOR SOĞAN KABUĞU ÖRNEĞİ

MUKADDES KILIÇ BAYRAKTAR, MELİKE SUGEÇTİ, EBRU YÜZLÜ · GIDA SEKTÖRÜNDE YENİ UYGULAMA ÖRNEKLERİ · 2025

Anti-nutritional and allergic components of taro: recent updates & perspectives

Amna Saqib, Aasma Asghar, Farhan Saeed · Food and Agricultural Immunology · 2025

Physicochemical and cooking properties of six pigeon pea (Cajanus cajan L) genotypes from Malawi

Tamara Tumasile Machinjili, Vernon Kabambe, Agnes M. Mwangwela · Frontiers in Sustainable Food Systems · 2025

Showing 8 of 9 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

0

Page views

0

PDF downloads

0

Outbound clicks

9

Citations

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

No views recorded yet.

Traffic sources

Referring site, by host.

No traffic recorded yet.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.