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Research Article Open access CC BY 4.0

Clinical Evaluation and Serum Lipid Profile between Individuals with Acute Hepatitis C

Sadia Qamar Arain, Farah Naz Talpur, Naseem Aslam Channa, Rehan Khan

International Journal of Biochemistry Research & Review · pp. 37–45 · Published 31 Dec 2014

10.9734/IJBCRR/2015/14989

Abstract

Clinical Evaluation and Serum Lipid Profile between Individuals with Acute Hepatitis C Aim: Hepatitis C virus (HCV) exerts an intense impact on host lipid metabolism. It has been shown that the synthesis of cholesterol and fatty acids (FA) is directly affected in HCV patients but serum FA profile of acute HCV patients have not been directly quantified in humans. Methodology: In present study the serum lipid and FA’s profile (free and total) of acute hepatitis C patients (n=50) is evaluated in comparison to healthy controls (n=50). The acute HCV patient’s were diagnosed by center of diseases control (CDC) criteria. Blood hematology, serum proteins, enzymes, waste metabolites and nutrition status were also assessed by standard methods. Results: The acute HCV patients have significantly lower (P<0.05) lipid profile including triglycerides, cholesterol, HDL and LDL in relation to controls.  Results of serum lipid FA’s (total and free form) reveal elevated level of saturated fatty acid (SFA) and monounsaturated fatty acid (MUFA), with lower content of polyunsaturated fatty acid (PUFA) in acute hepatitis C patient as compared to controls. Among SFA, myristic and palmitic acid were increased and five unsaturated FA including nervonic, linoleic, α-linolenic, docosahexaenoic and arachidonic acid were reduced than control subjects. Significantly higher (P<0.05) alanine transaminase, alkaline phosphatase, direct bilirubin and globulin levels were found in acute HCV patients possibly due to viral infection. Conclusion: This work makes available direct proof that lipogenesis is elevated in acute HCV patients while as evident from reduced serum PUFA and elevated SFA as well as MUFA. Hence acute HCV patients have low PUFA levels, which put forward importance of PUFA supplementation.

Complete picture of blood proteins and enzymes waste metabolites lipids GC–FID

References (24)

  1. 1 Inflammation and metabolic disorders [DOI]
  2. 2 De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation [DOI]
  3. 3 Free Fatty Acids Induce JNK-dependent Hepatocyte Lipoapoptosis [DOI]
  4. 4 The plasma lipidomic signature of nonalcoholic steatohepatitis†‡ [DOI]
  5. 5 Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome [Science 1989;244:359–362] [DOI]
  6. 6 Hemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis C virus infection: Role of membrane oxidative damage [DOI]
  7. 7 Nonstructural 3 Protein of Hepatitis C Virus Triggers an Oxidative Burst in Human Monocytes via Activation of NADPH Oxidase [DOI]
  8. 8 Role of lipid metabolism in hepatitis C virus assembly and entry [DOI]
  9. 9 Dietary fat: exogenous determination of membrane structure and cell function [DOI]
  10. 10 Hepatitis C Virus Infection Mimicking Primary Sjögren Syndrome [DOI]
  11. 11 Anti-HCV activities of selective polyunsaturated fatty acids [DOI]
  12. 12 Plasma Fatty Acid Composition as a Predictor of Arterial Stiffness and Mortality [DOI]
  13. 13 A Prospective, Community–Based Evaluation of Liver Enzymes in Individuals With Hepatitis C After Drug Use [DOI]
  14. 14 Pathogenesis of lipid metabolism disorder in hepatitis C: Polyunsaturated fatty acids counteract lipid alterations induced by the core protein [DOI]
  15. 15 Long‐term outcome of chronic hepatitis C after sustained virological response to interferon‐based therapy [DOI]
  16. 16 Increase in the Concentration of Carbon 18 Monounsaturated Fatty Acids in the Liver with Hepatitis C: Analysis in Transgenic Mice and Humans [DOI]
  17. 17 Impaired dendritic cell functions disrupt antigen-specific adaptive immune responses in mice with nonalcoholic fatty liver disease [DOI]
  18. 18 Metabolic investigations in patients with hepatitis B and C [DOI]
  19. 19 Acute hepatitis C infection lowers serum lipid levels [DOI]
  20. 20 Expression of CD81, SR‐BI and LDLR in lymphocytes and monocytes from patients with classic and occult hepatitis C virus infection [DOI]
  21. 21 Serum Lipoprotein Profiles and Response to Pegylated Interferon Plus Ribavirin Combination Therapy in Patients With Chronic HCV Genotype 1b Infection [DOI]
  22. 22 Liver enzymes and protein electrophoretic patterns in hemodialysis patients with antibodies against the hepatitis C virus.
  23. 23 Analysis of polyunsaturated fatty acids in blood serum after fish oil administration [DOI]
  24. 24 Chronic hepatitis C infection in a patient with bone marrow hypoplasia [DOI]

Cited by 7

A comparative study of serum lipid contents in pre and post IFN-alpha treated acute hepatitis C patients

Sadia Qamar Arain, Farah Naz Talpur, Naseem Aslam Channa · Lipids in Health and Disease · 2015

Serum lipid profile as a marker of liver impairment in hepatitis B Cirrhosis patients

Sadia Qamar Arain, Farah Naz Talpur, Naseem Aslam Channa · Lipids in Health and Disease · 2017

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