Correlation of Platelet Distribution Width [PDW], Mean Platelet Volume [MPV] and Red Cell Distribution Width [RDW] with Serum Blood Sugar Levels: A Case- control Study in the West Luck Now Population

Abstract

Background: Diabetes itself is known to have long standing complications of both micro-vascular as well as macro vascular type. One of the life threatening complications that diabetes gives rise to is stroke and Ischemic heart disease Altered thrombocyte morphology and function have been reported in patients with diabetes mellitus. Few researches have been conducted on complete blood count parameters like Platelet-Crit [Pct], Platelet distribution width [PDW], Mean Platelet Volume [MPV] and Red Cell Distribution width [RDW-SD, CV]. Aim: The aim of the present study was to determine the associations between platelet morphology markers like PDW, MPV and RDW with Fasting glucose (FBG), Post- prandial blood glucose [PPBG] and Random blood sugar[RBS] in long standing diabetics. Materials and Methods: Analyses were performed in 2 groups, one for cases and another for controls. A total of 240 patients, with 150 cases and 90 controls were analyzed over a period of 6 months. The data was collected from the hospital registry. Patient’s blood had been collected in Fluoride vials for sugar estimation [FBG, RBS, PPBS] and CBC for platelet parameters and RDW of the same patients was done. The identity of the patient was not disclosed and ethical approval was taken. Results: No significant correlation could be achieved between the tested parameters and the increased blood sugar level [p-value>0.05]. RDW-SD was seen to be an important diagnostic tool for interpretation if the sample size would have been adequate [ROC curve analysis]. Also in blood sugar level estimation, FBS, PPBS &RBS were found to be significantly increased. Conclusion: The FBS, RBS, PPBS were seen to be significantly increased in the case group as compared to the control group. There was no significant correlation seen between the platelet parameters, the RDW and Blood sugar parameters [p-value>0.05] .RDW was seen to be a good tool for investigation when ROC cure for RDW-SD was analyzed.