Evaluation of Different Aphrodisiac Therapy Effect by Using Some Biochemical Parameters in Female Wistar Albino Rats

Abstract

Since ancient times, humans across diverse tradition, cultures and religious background have shown keen interest in traditional herbal products which enhance sexual ability, pleasure and libido as well as improving sexual functions and potency. The use of herbal aphrodisiacs among men and women in Nigeria is on the high side.  This research aimed to study the effect of Mi jian fen (MJF) (a foreign aphrodisiac) and Tsumin marke (TM) (a local aphrodisiac) on female libido. The research also aimed at determining the possible effects of MJF and TM on some toxicological parameters. Eighteen Female wistar albino rats were selected randomly and assigned into six groups of three animals each. Group A served as the control group. Group B served as the standard rats in this group were given 0.2mg/kg dose of Clomid. Groups C and D were given low (0.2mg/kg) and high (0.4mg/kg) doses of MJF respectively. Groups E and F were given low (0.2mg/kg) and high (0.4mg/kg) doses of TM, respectively. All treatments were administered for a period of thirty days after which rats were sacrificed and blood samples collected. FSH, LH, Estrogen, ALT, AST, ALP, Urea, Creatinine and Hematological parameters were assayed using standard methods. At the end of the analysis, it was observed that the levels of LH increased significantly (p<0.05) in all the groups that were treated with high and low doses of MJF and TM, likewise FSH and estrogen. AST and ALT were slightly increased in all test groups while ALP was increased significantly (p<0.05) in all test groups. Urea increased significantly (p<0.05) in all test groups while creatinine increased slightly in all test groups. The results obtained confirmed MJF and TM to be potent aphrodisiacs. However, MJF shows to be a bit more libido enhancer them TM. The toxicity of MJF on the liver and kidney of the animals seem to be higher compared to that of TM. It is then concluded that long term usage of these substances could lead to clinical complications among human users.