Late-Onset Fibrodysplasia Ossificans Progressiva (FOP) or Munchmeyer’s Disease: A Case Report and Review of Clinical and Radiological Features

Abstract

Fibrodysplasia ossificans progressive (FOP) is a rare variety of myositis ossificans characterized by congenital malformations of the great toes and progressive heterotopic ossification that can induce a disabling second skeleton. We report a case of a 37-year-old female patient with late-onset Fibrodysplasia Ossificans Progressiva (FOP), presenting with disabling ankylosis and progressive heterotopic ossification since adolescence following trauma. The report outlines the clinical, radiological, and evolutionary aspects of FOP, with a focus on the diagnosis through classic congenital malformations of the toes and progressive ossification patterns. The paper underscores the challenges of managing such a rare disease, where early diagnosis and genetic confirmation are crucial for prognosis.