Evaluation of Antihyperlipidaemic Activities of Hydromethanolic Extracts of Dioscorea bulbifera
Bruno Chukwuemeka Chinko, Datonye Victor Dapper, Olaghaguo Maestephen Adienbo
Journal of Advances in Medical and Pharmaceutical Sciences · pp. 16–25 · Published 15 Feb 2020
10.9734/jamps/2020/v22i130151Abstract
Introduction: Hyperlipidemia is a leading cause of cardiovascular diseases (CHDs) with treatment ranging from dietary management and the use of antihyperlipidaemic drugs. The desire for anti-hyperlipidaemic drugs with less side effects has led to the screening of medical with anti-hyperlipidaemic properties. Aim: The present study is aimed at evaluating the effects of hydromethanolic extracts of Dioscorea bulbifera on high fat diet, tyloxapol and dexamethasone induced hyperlipidaemia using Wistar rat models. Methodology: Fifty five (55) adult male Wistar rats weighing 180-250 g were used for the study. Natural induction of hyperlipidaemia was done using a formulated High fat diet made from commercial rat chow and rendered cow fat while chemical induction of hyperlipidaemia was done using tyloxapol (200 mg/kg) and dexamethasone (20 mg/kg). The Wistar rats where divided into eleven (11) groups comprising four (5) control groups and seven (6) experimental groups. The extracts were used to treat the hyperlipidaemic rats at 200 mg/kg and 400 mg/kg while Simvastatin was used as a standard. Blood samples of the animals were analyzed for Total cholesterol (TC), Triglycerides (TG), High density lipoproteins (HDL), Low density lipoproteins (LDL), Very low density lipoprotein (VLDL) and Serum glucose were determined by standard enzymatic methods. Results: The results indicate that the hyperlipidaemic rats treated with extracts of Dioscorea bulbifera had significantly reduced TC, TG, LDL, VLDL and serum glucose compared with the control (untreated hyperlipidaemic rats) (P<0.05). In the same way, the HDL was found to be significantly higher among the treated hyperlipidaemic rats compared with the untreated controls. Conclusion: The present study shows that hydromethanolic extracts of Dioscorea bulbifera has a possible antihyperlipidaemic potentials as demonstrated by its ability to significantly improve lipid profile and lower serum glucose levels in hyperlipidaemic rat models.
References (41)
- 1 Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge [DOI]
- 2 The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate inapob-lipoprotein-depleted plasma (FERHDL) [DOI]
- 3 Inhibition of .ALPHA.-Glucosidase and .ALPHA.-Amylase by Flavonoids [DOI]
- 4 Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. [DOI]
- 5 2012 Update of the Canadian Cardiovascular Society Guidelines for the Diagnosis and Treatment of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult [DOI]
- 6 Inhibition of Alpha-glucosidase and Amylase by Luteolin, a Flavonoid [DOI]
- 7 Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice [DOI]
- 8 Atherogenic Index of Plasma (AIP): A marker of cardiovascular disease.
- 9 Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity [DOI]
- 10 A mechanism for the hypocholesterolaemic activity of saponins [DOI]
- 11 Body mass index and body energy stores in developing countries.
- 12 A Review Article on Hyperlipidemia: Types, Treatments and New Drug Targets [DOI]
- 13 Extracts of Maqui (Aristotelia chilensis) and Murta (Ugni molinae Turcz.): Sources of Antioxidant Compounds and α-Glucosidase/α-Amylase Inhibitors [DOI]
- 14 Diosgenin from Dioscorea bulbifera: Novel Hit for Treatment of Type II Diabetes Mellitus with Inhibitory Activity against α-Amylase and α-Glucosidase [DOI]
- 15 Antitumor-Promoting Constituents from Dioscorea bulbifera L. in JB6 Mouse Epidermal Cells. [DOI]
- 16 Antidiabetic activities of aqueous leaves extract of Leonotis leonurus in streptozotocin induced diabetic rats [DOI]
- 17 Drug Therapy of Postprandial Hyperglycaemia [DOI]
- 18 Effect of diosgenin on lipid metabolism in rats. [DOI]
- 19 Protective effect of lupeol and its ester on cardiac abnormalities in experimental hypercholesterolemia [DOI]
- 20 Igbo Traditional Food System: Documentation, Uses and Research Needs [DOI]
- 21 Effects of diet-induced hypercholesterolemia on the lipid profile and some enzyme activities in female Wistar rats [DOI]
- 22 Phytochemical screening to validate the ethnobotanical importance of root tubers of Dioscorea species of Meghalaya, North East India
- 23 Bioactivity, toxicity and detoxification assessment of Dioscorea bulbifera L.: a comprehensive review [DOI]
- 24 The effect of the gastrointestinal lipase inhibitor, orlistat, on serum lipids and lipoproteins in patients with primary hyperlipidaemia [DOI]
- 25 Adverse Effects of Hypolipidaemic Drugs [DOI]
- 26 Antihyperlipidemic potential of a polyherbal preparation on triton WR 1339 (Tyloxapol) induced hyperlipidemia: A comparison with lovastatin [DOI]
- 27 Phytochemsitry and Therapeutic Potential of Medicinal Plant: Dioscorea bulbifera [DOI]
- 28 Modern risk stratification in coronary heart disease.
- 29 Saponin as regulator of biofuel: implication for ethnobotanical management of diabetes [DOI]
- 30 Hyperlipidemia induced by Triton WR1339 (Tyloxapol) in Wistar rats
- 31 Assessment of lipid lowering effect of Sida rhomboidea.Roxb methanolic extract in experimentally induced hyperlipidemia [DOI]
- 32 Steroidal saponin diosgenin from Dioscorea bulbifera protects cardiac cells from hypoxia -reoxygenation injury through modulation of pro -survival and pro -death molecules [DOI]
- 33 Screening of antioxidant potentials in Dioscorea bulbifera
- 34 A Mini-Review on Hyperlipidemia: Common Clinical Problem [DOI]
- 35 Wound healing activity of Dioscorea bulbifera Linn.
- 36 Serum and liver lipids distributions in streptozotocin induced diabetic rat treated with diet containing yam (Dioscorea bulbifera) flour. [DOI]
- 37 A Preclinical Evaluation on Antioxidant and Gastroprotective Effect of Dioscorea Bulbifera in Wistar Rats
- 38 The Effect of Crude Diosgenin Extract from Purple and Yellow Greater Yams (Dioscorea alata L.) on the Lipid Profile of Dyslipidemia Rats [DOI]
- 39 Biotransformation of cholesterol to diosgenin by freely suspended and immobilised cells ofDioscorea bulbiferaL. [DOI]
- 40 Phytochemical investigations of Dioscorea bulbifera linn
- 41 HYPOLIPIDEMIC EFFECT OF EXTRACTS FROM ABELMOSCHUS ESCULENTUS L. – MALVACEAE ON TYLOXAPOL- INDUCED HYPERLIPIDEMIA IN MICE [DOI]
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