Evaluation of Hemidesmus indicus Plant Compounds for Anti-Cancer Studies –  An In silico Approach

Pavan Kumar Tummala; Sreeja Nannapaneni; Sumana Pratyusha Durvasula; Supriya Chadalavada; Sunandini Venigandla; Srikanth Vemuru; Suryanarayana Veeravilli; Maheswara Reddy Mallu

doi:10.9734/jpri/2021/v33i26A31472

Research Article Open access CC BY 4.0

Evaluation of Hemidesmus indicus Plant Compounds for Anti-Cancer Studies – An In silico Approach

Pavan Kumar Tummala, Sreeja Nannapaneni, Sumana Pratyusha Durvasula, Supriya Chadalavada, Sunandini Venigandla, Srikanth Vemuru, Suryanarayana Veeravilli, Maheswara Reddy Mallu

Journal of Pharmaceutical Research International · pp. 64–69 · Published 26 Apr 2021

10.9734/jpri/2021/v33i26A31472

Abstract

Background: Phytocompounds in medicinal plants have a wide range of properties and are alternative medicines for those who cannot be helped by conventional medicine. Objective: In this work we have selected bioactive compounds from Hemidesmus indicus medicinal plant extracts. Methods: Gas chromatography and Mass spectrum studies were studied to identify the compounds present in the ethanolic extracts based on the retention time and area. Results: The identified compounds were used for anti-cancer activity by insilico method with BCL-2 which plays prominent role in causing cancer. Conclusion: Out of twenty selected compounds, docking results showedMethyl-1-Cyclohexane carboxylate and 1,2-diacetoxy-5-idohexane as best docked to the BCL-2.

Hemidesmus indicus anti-diabetic anticancer docking studies alpha glucosidase

Cited by 2

2 citations reported by external sources — individual citing-article records aren't available to list yet.

Molecules of Interest – Mangiferin – A Review — shares topic coverage
Antimutagenicity and Anticancer Effects of Biebersteinia multifida DC — shares topic coverage
Investigation of Novel Tetrahalometallate Complexes of Cetrimonium Bromide Surfactant against in vitro Human Tumour Cell Lines of Lung, Colon and Liver — shares topic coverage
Phytochemical Screening, Total Phenolic Content, Antioxidant and Cytotoxic Activity of Chromolaena laevigata on Human Tumor Cell Lines — shares topic coverage
Phytochemical, Pharmaceutical and Biochemical Activites of Selected Climber Plants: A Review — shares topic coverage

Access this article

View at publisher

Cite this article

Pavan Kumar Tummala, Sreeja Nannapaneni, Sumana Pratyusha Durvasula, Supriya Chadalavada, Sunandini Venigandla, Srikanth Vemuru, Suryanarayana Veeravilli, Maheswara Reddy Mallu (2021). Evaluation of Hemidesmus indicus Plant Compounds for Anti-Cancer Studies – An In silico Approach. Journal of Pharmaceutical Research International , 64–69. https://doi.org/10.9734/jpri/2021/v33i26A31472

Affiliations

Pavan Kumar Tummala — Department of Computer Science and Engineering, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India.
Sreeja Nannapaneni — Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India.
Sumana Pratyusha Durvasula — Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India.
Supriya Chadalavada — Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India.
Sunandini Venigandla — Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India.
Srikanth Vemuru — Department of Computer Science and Engineering, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India.
Suryanarayana Veeravilli — Department of Humanities and Basic Sciences, Aditya Engineering College, Surampalem, Andhra Pradesh, India.
Maheswara Reddy Mallu — Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India.

Metrics

0
Views: 0
Downloads: 2
Citations: 0
Outbound

Full metrics

Article metrics

Real usage data collected on this platform.

0

Page views

0

PDF downloads

0

Outbound clicks

2

Citations

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

No views recorded yet.

Traffic sources

Referring site, by host.

No traffic recorded yet.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.